Up to 2,100 retail and commercial workers at Barclays are in danger of losing their jobs, inthenews.co.uk understands.
A source explained that a maximum of 2,100 redundancies could be announced across the bank's Barclaycard, retail banking and commercial banking divisions.
Yesterday the bank announced a completely separate set of redundancies in its investment banking and investment management (IBIM) arm that could also see up to 2,100 jobs shed.
A Barclays source said the company was "so early" in the process of deciding redundancies that it would take many months to come to a total figure.
It is expected that the actual number of job losses will be "significantly lower" than 4,200.
An official statement from the bank, like other financial institutions suffering greatly from the global slowdown, said it was especially important in current conditions to ensure its businesses were efficient.
"Barclays is in consultation with Unite on a range of programmes where we are actively working together to minimise the numbers of our people affected by change," Barclays said.
"This is the way we always work in partnership with Unite, which we believe results in the best outcomes for our colleagues and the organisation.
"We will take all possible measures to mitigate compulsory redundancies through redeployment, using natural attrition, releasing of contractors, closing vacancies and opening voluntary redundancy registers."
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